The Cathedral of Sansepolcro (Italian: Duomo di Sansepolcro; officially a co-cathedral) is a Catholic church in Sansepolcro, Tuscany, central Italy.
The church, formerly an abbey church, occupies the site of the town's first Benedictine monastery. This, built in the 10th century, was acquired by the Camaldolese during the 12th century.
The church was constructed in 1012–1049, initially dedicated to the Four Evangelists and the Holy Sepulchre (deriving from Sansepolcro's name). According to the legend, their relics had been brought here from the Holy Land by two local pilgrims, Egidio and Arcano. The abbey was rebuilt in the late 13th century. In 1520, when pope Leo X established the diocese of Sansepolcro, the church became its cathedral and was re-dedicated to the city's patron, St. John the Evangelist.
Large restoration works were carried on between 1934 and 1943, destroying most of the Baroque elements added in the course of the centuries to the original medieval edifice. Several frescoes by the Riminese school and by Bartolomeo della Gatta (14th-15th centuries) become visible again, and a new chapel, called Cappella del Volto Santo, was added to house the so-called "Holy Face" icon, previously located at the altar. A new choir was built in 1966–1967.
The church became a co-cathedral with the merge of the dioceses of Arezzo, Sansepolcro and Cortona in 1986.
With the exception of the apse area, the church has maintained the 14th century basilica plan with a nave and two aisles. Romanesque elements include the internal round arcades, the capitals and the general proportions. More influenced by Gothic (a style which was becoming widespread when the church was being built) are the portal of the façade and window above. The rose window is the result of a later restoration.