Catechol melanin

Melanin ⁱ/ˈmɛlənɪn/ (Greek: μέλας – melas, "black, dark") is a broad term for a group of natural pigments found in most organisms. Melanin is produced by the oxidation of the amino acid tyrosine, followed by polymerization. The pigment is produced in a specialized group of cells known as melanocytes.

There are three basic types of melanin: eumelanin, pheomelanin, and neuromelanin. The most common is eumelanin, of which there are two types—brown eumelanin and black eumelanin. Pheomelanin is a cysteine-containing red polymer of benzothiazine units largely responsible for red hair, among other pigmentation. Neuromelanin is found in the brain, though its function remains obscure.

In the skin, melanogenesis occurs after exposure to UV radiation, causing the skin to visibly tan. Melanin is an effective absorber of light; the pigment is able to dissipate over 99.9% of absorbed UV radiation. Because of this property, melanin is thought to protect skin cells from UVB radiation damage, reducing the risk of cancer. Furthermore, though exposure to UV radiation is associated with increased risk of malignant melanoma, a cancer of the melanocytes, studies have shown a lower incidence for skin cancer in individuals with more concentrated melanin, i.e. darker skin tone. Nonetheless, the relationship between skin pigmentation and photoprotection is still being clarified.

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