Catechol-o-methyl transferase

COMT

Catechol-O-methyl transferase 3bwm.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD

Identifiers

COMT, HEL-S-98n, catechol-O-methyltransferase

External IDs

OMIM: 116790 MGI: 88470 HomoloGene: 30982 GeneCards: COMT

Targeted by Drug

entacapone, tolcapone

Gene ontology
Molecular function	• transferase activity • O-methyltransferase activity • metal ion binding • protein binding • magnesium ion binding • catechol O-methyltransferase activity • methyltransferase activity • L-dopa O-methyltransferase activity
Cellular component	• cytoplasm • integral component of membrane • cell body • cytosol • postsynaptic membrane • membrane • plasma membrane • dendritic spine • axon • dendrite • mitochondrion • extracellular exosome
Biological process	• multicellular organismal reproductive process • negative regulation of smooth muscle cell proliferation • response to organic cyclic compound • regulation of sensory perception of pain • estrogen metabolic process • cellular response to phosphate starvation • catechol-containing compound metabolic process • female pregnancy • negative regulation of dopamine metabolic process • developmental process • learning • catecholamine metabolic process • neurotransmitter catabolic process • response to lipopolysaccharide • methylation • dopamine metabolic process • response to pain • short-term memory • negative regulation of renal sodium excretion • dopamine catabolic process • response to drug • positive regulation of homocysteine metabolic process
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE COMT 208817 at tn.png

PBB GE COMT 208818 s at tn.png

PBB GE COMT 213981 at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


1312


12846


ENSG00000093010


n/a


P21964


O88587

RefSeq (mRNA)


NM_000754 NM_001135161 NM_001135162 NM_007310


NM_001111062 NM_001111063 NM_007744

RefSeq (protein)


NP_000745 NP_001128633 NP_001128634 NP_009294

NP_001104532.1 NP_001104533.1 NP_031770.2 NP_001104532 NP_001104533
NP_031770

Location (UCSC)

Chr 22: 19.94 – 19.97 Mb

Chr 16: 18.41 – 18.43 Mb

PubMed search

catechol-O-methyltransferase

Identifiers

Databases

metabolic pathway

PDB structures

RCSB PDB PDBe PDBsum

Search
PMC	articles
PubMed	articles
NCBI	proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD

ENSG00000093010

n/a

NM_000754
NM_001135161
NM_001135162
NM_007310

NM_001111062
NM_001111063
NM_007744

NP_000745
NP_001128633
NP_001128634
NP_009294

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Wikipedia

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