Catechol-O-methyltransferase

COMT

Catechol-O-methyl transferase 3bwm.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD

Identifiers

COMT, HEL-S-98n, catechol-O-methyltransferase

External IDs

OMIM: 116790 MGI: 88470 HomoloGene: 30982 GeneCards: COMT

Gene location (Human)

Chr.	Chromosome 22 (human)

Band	22q11.21	Start	19,941,607 bp
Band	22q11.21	End	19,969,975 bp

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)

Band	n/a	Start	18,406,886 bp
Band	n/a	End	18,426,852 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • O-methyltransferase activity • metal ion binding • protein binding • magnesium ion binding • catechol O-methyltransferase activity • methyltransferase activity • L-dopa O-methyltransferase activity • orcinol O-methyltransferase activity
Cellular component	• cytoplasm • integral component of membrane • cell body • cytosol • postsynaptic membrane • membrane • plasma • dendritic spine • axon • dendrite • mitochondrion • extracellular exosome
Biological process	• multicellular organismal reproductive process • negative regulation of smooth muscle cell proliferation • response to organic cyclic compound • regulation of sensory perception of pain • estrogen metabolic process • cellular response to phosphate starvation • catechol-containing compound metabolic process • female pregnancy • negative regulation of dopamine metabolic process • developmental process • learning • catecholamine metabolic process • neurotransmitter catabolic process • response to lipopolysaccharide • methylation • dopamine metabolic process • response to pain • short-term memory • negative regulation of renal sodium excretion • dopamine catabolic process • response to drug • positive regulation of homocysteine metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


1312


12846


ENSG00000093010


n/a


P21964


O88587

RefSeq (mRNA)


NM_000754 NM_001135161 NM_001135162 NM_007310


NM_001111062 NM_001111063 NM_007744

RefSeq (protein)


NP_000745 NP_001128633 NP_001128634 NP_009294


NP_001104532 NP_001104533 NP_031770

Location (UCSC)

Chr 22: 19.94 – 19.97 Mb

Chr 22: 18.41 – 18.43 Mb

PubMed search

catechol-O-methyltransferase

Identifiers

Databases

metabolic pathway

PDB structures

RCSB PDB PDBe PDBsum

AmiGO / QuickGO

Search
PMC	articles
PubMed	articles
NCBI	proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD

ENSG00000093010

n/a

NM_000754
NM_001135161
NM_001135162
NM_007310

NM_001111062
NM_001111063
NM_007744

NP_000745
NP_001128633
NP_001128634
NP_009294

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Wikipedia

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