CatSper1

CATSPER1
Identifiers
Aliases	CATSPER1, CATSPER, SPGF7, CatSper1, cation channel sperm associated 1
External IDs	MGI: 2179947 HomoloGene: 14207 GeneCards: CATSPER1
Targeted by Drug
alprostadil, dinoprostone, progesterone, mibefradil
Gene ontology Molecular function • calcium activated cation channel activity • calcium channel activity • voltage-gated ion channel activity • ion channel activity • protein binding • voltage-gated calcium channel activity • high voltage-gated calcium channel activity Cellular component • integral component of membrane • CatSper complex • cell projection • membrane • plasma membrane • cilium • motile cilium Biological process • fusion of sperm to egg plasma membrane • regulation of cilium beat frequency involved in ciliary motility • cell differentiation • regulation of calcium ion transport • membrane depolarization during action potential • regulation of ion transmembrane transport • ion transport • multicellular organism development • calcium ion transmembrane transport • transmembrane transport • spermatogenesis • sperm-egg recognition • transport • calcium ion transport • response to progesterone • flagellated sperm motility Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117144	225865
Ensembl	ENSG00000175294	ENSMUSG00000038498
UniProt	Q8NEC5	Q91ZR5
RefSeq (mRNA)	NM_053054	NM_139301
RefSeq (protein)	NP_444282	NP_647462.1 NP_647462
Location (UCSC)	Chr 11: 66.02 – 66.03 Mb	Chr 19: 5.34 – 5.34 Mb
PubMed search

117144

225865

ENSG00000175294

ENSMUSG00000038498

Q8NEC5

Q91ZR5

NM_053054

NM_139301

NP_444282

NP_647462.1
NP_647462

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene. CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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