Caspase-3

CASP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M, 2C2O, 2CDR, 2CJX, 2CJY, 2CNK, 2CNL, 2CNN, 2CNO, 2DKO, 2H5I, 2H5J, 2H65, 2J30, 2J31, 2J32, 2J33, 2XYG, 2XYH, 2XYP, 2XZD, 2XZT, 2Y0B, 3DEH, 3DEI, 3DEJ, 3DEK, 3EDQ, 3GJQ, 3GJR, 3GJS, 3GJT, 3H0E, 3ITN, 3KJF, 3PCX, 3PD0, 3PD1, 4DCJ, 4DCO, 4DCP, 4EHA, 4EHD, 4EHF, 4EHH, 4EHK, 4EHL, 4EHN, 4JJE, 4JQY, 4JQZ, 4JR0, 4PRY, 4PS0, 4QTX, 4QTY, 4QU0, 4QU5, 4QU8, 4QU9, 4QUA, 4QUB, 4QUD, 4QUE, 4QUG, 4QUH, 4QUI, 4QUJ, 4QUL, 5IC4
Identifiers
Aliases	CASP3, CPP32, CPP32B, SCA-1, caspase 3
External IDs	OMIM: 600636 MGI: 107739 HomoloGene: 37912 GeneCards: CASP3
Gene ontology Molecular function • death receptor binding • cysteine-type peptidase activity • protein complex binding • protease binding • peptidase activity • protein binding • phospholipase A2 activator activity • cyclin-dependent protein serine/threonine kinase inhibitor activity • cysteine-type endopeptidase activity involved in apoptotic process • cysteine-type endopeptidase activity involved in execution phase of apoptosis • cysteine-type endopeptidase activity • hydrolase activity • cysteine-type endopeptidase activator activity involved in apoptotic process • aspartic-type endopeptidase activity Cellular component • cytoplasm • cytosol • plasma membrane • nucleoplasm • death-inducing signaling complex • membrane raft • nucleus Biological process • cellular response to organic substance • neuron apoptotic process • cell fate commitment • response to estradiol • intracellular signal transduction • response to hypoxia • response to amino acid • apoptotic DNA fragmentation • response to organic cyclic compound • negative regulation of cyclin-dependent protein serine/threonine kinase activity • response to antibiotic • platelet formation • protein processing • response to nicotine • response to metal ion • negative regulation of cell cycle • wound healing • response to glucocorticoid • cellular response to organic cyclic compound • B cell homeostasis • negative regulation of apoptotic process • sensory perception of sound • response to glucose • response to organic substance • hippo signaling • glial cell apoptotic process • keratinocyte differentiation • proteolysis • cellular response to DNA damage stimulus • T cell homeostasis • response to tumor necrosis factor • negative regulation of activated T cell proliferation • heart development • response to lipopolysaccharide • positive regulation of neuron apoptotic process • response to wounding • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c • neuron differentiation • extrinsic apoptotic signaling pathway in absence of ligand • learning or memory • positive regulation of apoptotic process • erythrocyte differentiation • apoptotic signaling pathway • negative regulation of B cell proliferation • response to cobalt ion • hippocampus development • response to UV • response to X-ray • response to drug • response to hydrogen peroxide • regulation of macroautophagy • apoptotic process • neurotrophin TRK receptor signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic process • execution phase of apoptosis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	836	12367
Ensembl	ENSG00000164305	ENSMUSG00000031628
UniProt	P42574	P70677
RefSeq (mRNA)	NM_004346 NM_032991	NM_009810 NM_001284409
RefSeq (protein)	NP_004337 NP_116786	NP_001271338.1 NP_033940.1 NP_001271338 NP_033940
Location (UCSC)	Chr 4: 184.63 – 184.65 Mb	Chr 8: 46.62 – 46.64 Mb
PubMed search

1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M, 2C2O, 2CDR, 2CJX, 2CJY, 2CNK, 2CNL, 2CNN, 2CNO, 2DKO, 2H5I, 2H5J, 2H65, 2J30, 2J31, 2J32, 2J33, 2XYG, 2XYH, 2XYP, 2XZD, 2XZT, 2Y0B, 3DEH, 3DEI, 3DEJ, 3DEK, 3EDQ, 3GJQ, 3GJR, 3GJS, 3GJT, 3H0E, 3ITN, 3KJF, 3PCX, 3PD0, 3PD1, 4DCJ, 4DCO, 4DCP, 4EHA, 4EHD, 4EHF, 4EHH, 4EHK, 4EHL, 4EHN, 4JJE, 4JQY, 4JQZ, 4JR0, 4PRY, 4PS0, 4QTX, 4QTY, 4QU0, 4QU5, 4QU8, 4QU9, 4QUA, 4QUB, 4QUD, 4QUE, 4QUG, 4QUH, 4QUI, 4QUJ, 4QUL, 5IC4

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