Caspase-1

CASP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7, 5FNA
Identifiers
Aliases	CASP1, ICE, IL1BC, P45, caspase 1
External IDs	OMIM: 147678 MGI: 96544 HomoloGene: 133272 GeneCards: CASP1
Gene ontology Molecular function • cysteine-type peptidase activity • endopeptidase activity • peptidase activity • protein binding • cysteine-type endopeptidase activity involved in apoptotic process • cysteine-type endopeptidase activator activity involved in apoptotic process • cysteine-type endopeptidase activity • hydrolase activity Cellular component • NLRP3 inflammasome complex • cytoplasm • cytosol • NLRP1 inflammasome complex • extracellular region • AIM2 inflammasome complex • IPAF inflammasome complex • mitochondrion Biological process • cellular response to organic substance • response to ATP • response to hypoxia • response to bacterium • membrane hyperpolarization • pyroptosis • positive regulation of interleukin-1 alpha secretion • positive regulation of cytokine secretion • protein processing • toxin transport • proteolysis • cellular response to mechanical stimulus • response to lipopolysaccharide • regulation of autophagy • positive regulation of interleukin-1 beta secretion • regulation of inflammatory response • interleukin-1 beta production • positive regulation of I-kappaB kinase/NF-kappaB signaling • mitochondrial depolarization • programmed necrotic cell death • signal transduction • apoptotic process • regulation of apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	834	12362
Ensembl	ENSG00000137752	ENSMUSG00000025888
UniProt	P29466	P29452
RefSeq (mRNA)	NM_001223 NM_001257118 NM_001257119 NM_033292 NM_033293 NM_033294 NM_033295	NM_009807
RefSeq (protein)	NP_001214 NP_001244047 NP_001244048 NP_150634 NP_150635 NP_150636 NP_150637	NP_033937.2
Location (UCSC)	Chr 11: 105.03 – 105.04 Mb	Chr 9: 5.3 – 5.31 Mb
PubMed search

1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7, 5FNA

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