Casimir of Bytom (Polish: Kazimierz bytomski) (1253/57 – 10 March 1312) was a Duke of Opole during 1282–1284 (with his brother as co-ruler) and Duke of Bytom from 1284 until his death.
He was the second son of Władysław, Duke of Opole–Racibórz, by his wife Euphemia, daughter of Władysław Odonic, Duke of Greater Poland.
Little is known about the first years of Casimir's life. By 1264, he was knighted by King Ottokar II of Bohemia and with this began his politic activities with his father.
After the death of his father in 1282, Casimir inherited the Duchy of Opole with his brother Bolko I as co-rulers. The common rule between them lasted until 1284, when they decided to make a formal division of their domains: Casimir took the towns of Bytom (the main city and now capital of his Duchy), Koźle, Toszek, Gliwice and Siewierz.
There are few reports of Casimir's independent rule. Certainly at the end of the 1280s he and his brothers Mieszko I and Przemysław supported the Bishop of Wrocław, Thomas II Zaremba in his conflict with Henry IV Probus, the powerful Duke of Wrocław -their other brother Bolko I unexpectedly supported Henry IV. The cause of the bad relations between Władysław Opolski's sons and the Duke of Wrocław possibly started when Henry IV repudiated his wife Constance (sister of the Opole-Racibórz brothers) and sent her back home. The reasons for this repudiation are disputed among historians, but it probably was because of the Constance's suspected infertility.