Casein kinase 2

Identifiers

Aliases

External IDs

GeneCards: [1]

Orthologs

Species

Human

Mouse

Entrez


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Ensembl


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UniProt


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RefSeq (mRNA)


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RefSeq (protein)


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Location (UCSC)

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PubMed search

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casein kinase 2, alpha 1 polypeptide
Identifiers
Symbol	CSNK2A1
Entrez	1457
HUGO	2457
OMIM	115440
RefSeq	NM_001895
UniProt	P68400
Other data
EC number	2.7.11.1
Locus	Chr. 20 p13

casein kinase 2, alpha prime polypeptide
Identifiers
Symbol	CSNK2A2
Entrez	1459
HUGO	2459
OMIM	115442
RefSeq	NM_001896
UniProt	P19784
Other data
EC number	2.7.11.1
Locus	Chr. 16 [2]

casein kinase 2, beta polypeptide
Identifiers
Symbol	CSNK2B
Entrez	1460
HUGO	2460
OMIM	115441
RefSeq	NM_001320
UniProt	P67870
Other data
EC number	2.7.11.1
Locus	Chr. 6 p21.3

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The casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.

Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation. A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.

Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.

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Wikipedia