Carnitine palmitoyltransferase I

CPT1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LE3
Identifiers
Aliases	CPT1A, carnitine palmitoyltransferase 1A (liver), CPT1, CPT1-L, L-CPT1, carnitine palmitoyltransferase 1A
External IDs	MGI: 1098296 HomoloGene: 1413 GeneCards: CPT1A
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.3 Start 68,754,620 bp End 68,844,410 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 A|19 3.08 cM Start 3,323,301 bp End 3,385,732 bp
Gene ontology Molecular function • transferase activity • carnitine O-palmitoyltransferase activity • palmitoleoyltransferase activity • identical protein binding • transferase activity, transferring acyl groups Cellular component • integral component of membrane • membrane • intracellular membrane-bounded organelle • integral component of mitochondrial outer membrane • mitochondrial outer membrane • mitochondrion • mitochondrial inner membrane Biological process • carnitine shuttle • positive regulation of fatty acid beta-oxidation • epithelial cell differentiation • response to organic cyclic compound • eating behavior • regulation of fatty acid oxidation • regulation of insulin secretion • lipid metabolic process • fatty acid metabolic process • cellular response to fatty acid • circadian rhythm • glucose metabolic process • fatty acid beta-oxidation • long-chain fatty acid metabolic process • protein homooligomerization • triglyceride metabolic process • response to drug • carnitine metabolic process • regulation of lipid metabolic process • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1374	12894
Ensembl	ENSG00000110090	ENSMUSG00000024900
UniProt	P50416	P97742
RefSeq (mRNA)	NM_001031847 NM_001876	NM_013495
RefSeq (protein)	NP_001027017 NP_001867	NP_038523
Location (UCSC)	Chr 11: 68.75 – 68.84 Mb	Chr 11: 3.32 – 3.39 Mb
PubMed search

2LE3

1374

12894

ENSG00000110090

ENSMUSG00000024900

P50416

P97742

NM_001031847
NM_001876

NM_013495

NP_001027017
NP_001867

NP_038523

Carnitine palmitoyltransferase I (CPT1) also known as carnitine acyltransferase I, CPTI, CAT1, CoA:carnitine acyl transferase (CCAT), or palmitoylCoA transferase I, is a enzyme responsible for the formation of acyl carnitines by catalyzing the transfer of the acyl group of a long-chain fatty acyl-CoA from coenzyme A to l-carnitine. The product is often Palmitoylcarnitine (thus the name), but other fatty acids may also be substrates. It is part of a family of enzymes called carnitine acyltransferases. This "preparation" allows for subsequent movement of the acyl carnitine from the cytosol into the intermembrane space of mitochondria.

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