Francisco Jiménez de Cisneros, O.F.M. (1436 – 8 November 1517), known as Ximenes de Cisneros in his own lifetime, and commonly referred to today as simply Cisneros, was a Spanish cardinal, religious figure, and . Starting from humble beginnings he rose to the heights of power becoming a religious reformer, twice regent of Spain, Cardinal, Grand Inquisitor, promoter of the Crusades in North Africa, and founder of the Complutense University, today the Complutense University of Madrid. Among his intellectual accomplishments, he is best known for funding the Complutensian Polyglot Bible, the first printed polyglot version of the entire Bible. He also edited and published the first printed editions of the missal (in 1500) and the breviary (in 1502) of the Mozarabic Rite, and established a chapel with a college of thirteen priests to celebrate the Mozarabic Liturgy of the Hours and Eucharist each day in the Toledo Cathedral.
Cardinal Cisneros' life coincided with, and greatly influenced, a dynamic period in the history of Spain during the reign of Ferdinand II of Aragon and Isabella I of Castile. During this time Spain underwent many significant changes, leading it into its prominent role in the Spanish Golden Age (1500–1700). Modern historian John Elliott said as far as any particular policies that can be attributed to Spain's rise, they were those of King Ferdinand and Cardinal Cisneros.
He was born as Gonzalo Jiménez de Cisneros in Torrelaguna in Castile in 1436, the son of hidalgos Alfonso Jiménez y María de la Torre, from the villa of Cisneros, Palencia. He studied at Alcalá de Henares and Salamanca, where in 1456, he obtained a bachelor's degree in law. In 1459, he traveled to Rome to work as a consistorial advocate where he attracted the notice of Pope Pius II. He returned to Spain in 1465 carrying an "executive" letter from the Pope giving him possession of the first vacant benefice. That turned out to be Uceda. However, Alfonso Carrillo de Acuña, the Archbishop of Toledo and Primate of Spain, refused to accept the letter, wishing instead to bestow the benefice upon one of his own followers. When Cisneros insisted, he was thrown in prison, first at Uzeda and afterwards in the fortress of Santorcaz. For six years, Cisneros held out for his claim, free to leave at any time if he would give it up, but at length in 1480 Carillo relented at Cisneros' strength of conviction and gave him a benefice. Fearing further reprisals, Cisneros traded it almost at once for a chaplaincy at Sigüenza, under Cardinal Pedro González de Mendoza, the bishop of Sigüenza, who shortly after appointed him vicar general of his diocese.