Pedro González de Mendoza (May 3, 1428 – January 11, 1495) was a Spanish cardinal and who served as Archbishop of Toledo (1482–1495), Archbishop of Sevilla (1474–1482), Bishop of Sigüenza (1467–1474), and Bishop of Calahorra y La Calzada (1453–1467).
He was born at Guadalajara in New Castile, the chief lordship of his family. He was the fourth son of Íñigo López de Mendoza, marqués de Santillana, deceased 1458, and one of the cadet brothers of Diego Hurtado de Mendoza, 1. duque of l'Infantado and Íñigo López de Mendoza, 1st count of Tendilla.
The house of Mendoza claimed to descend from the lords of Llodio in Alava, and to have been settled in Old Castile, in the 11th century. One chief of the house had been greatly distinguished at the battle of Las Navas de Tolosa in 1212. Another, Diego Hurtado de Mendoza, his grandfather, (circa 1365 - 1404), had been Admiral of Castile in the reign of Henry III of Castile "The Infirm".
King Pedro I of Castile, assassinated March 1369, had endowed his great grandfather Pedro González de Mendoza, killed at the Battle of Aljubarrota in 1385, with the lordships of Hita in the province of Guadalajara, and Buitrago.