Carbohydrate-binding module
| CBM_1 | |||||||||
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three-dimensional structures of three engineered cellulose-binding domains of cellobiohydrolase i from trichoderma reesei, nmr, 18 structures
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| Identifiers | |||||||||
| Symbol | CBM_1 | ||||||||
| Pfam | PF00734 | ||||||||
| InterPro | IPR000254 | ||||||||
| PROSITE | PDOC00486 | ||||||||
| SCOP | 1cel | ||||||||
| SUPERFAMILY | 1cel | ||||||||
| CAZy | CBM1 | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
| CBM_2 | |||||||||
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solution structure of a cellulose binding domain from cellulomonas fimi by nuclear magnetic resonance spectroscopy
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| Identifiers | |||||||||
| Symbol | CBM_2 | ||||||||
| Pfam | PF00553 | ||||||||
| Pfam clan | CL0203 | ||||||||
| InterPro | IPR001919 | ||||||||
| PROSITE | PDOC00485 | ||||||||
| SCOP | 1exg | ||||||||
| SUPERFAMILY | 1exg | ||||||||
| CAZy | CBM2 | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
| CBM_3 | |||||||||
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crystal structure of a family iiia cbd from clostridium cellulolyticum
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| Identifiers | |||||||||
| Symbol | CBM_3 | ||||||||
| Pfam | PF00942 | ||||||||
| Pfam clan | CL0203 | ||||||||
| InterPro | IPR001956 | ||||||||
| SCOP | 1nbc | ||||||||
| SUPERFAMILY | 1nbc | ||||||||
| CAZy | CBM3 | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
| CBM_5/12 | |||||||||
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interactions of a family 18 chitinase with the designed inhibitor hm508, and its degradation product, chitobiono-delta-lactone
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| Identifiers | |||||||||
| Symbol | CBM_5_12 | ||||||||
| Pfam | PF02839 | ||||||||
| InterPro | IPR003610 | ||||||||
| SCOP | 1ed7 | ||||||||
| SUPERFAMILY | 1ed7 | ||||||||
| CAZy | CBM12 | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
| CBM_6 | |||||||||
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cbm6ct from clostridium thermocellum in complex with xylopentaose
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| Identifiers | |||||||||
| Symbol | CBM_6 | ||||||||
| Pfam | PF03422 | ||||||||
| Pfam clan | CL0202 | ||||||||
| InterPro | IPR005084 | ||||||||
| SCOP | 1gmm | ||||||||
| SUPERFAMILY | 1gmm | ||||||||
| CAZy | CBM6 | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
In molecular biology, a carbohydrate-binding module (CBM) is a protein domain found in carbohydrate-active enzymes (for example glycoside hydrolases). The majority of these domains have carbohydrate-binding activity. Some of these domains are found on cellulosomal scaffoldin proteins. CBMs were previously known as cellulose-binding domains. CBMs are classified into numerous families, based on amino acid sequence similarity. There are currently (June 2011) 64 families of CBM in the CAZy database.
CBMs of microbial glycoside hydrolases play a central role in the recycling of photosynthetically fixed carbon through their binding to specific plant structural polysaccharides. CBMs can recognise both crystalline and amorphous cellulose forms. CBMs are the most common non-catalytic modules associated with enzymes active in plant cell-wall hydrolysis. Many putative CBMs have been identified by amino acid sequence alignments but only a few representatives have been shown experimentally to have a carbohydrate-binding function.
Carbohydrate-binding module family 1 (CBM1) consists of 36 amino acids. This domain contains 4 conserved cysteine residues which are involved in the formation of two disulfide bonds.
Carbohydrate-binding module family 2 (CBM2) contains two conserved cysteines - one at each extremity of the domain - which have been shown to be involved in a disulfide bond. There are also four conserved tryptophans, two of which are involved in cellulose binding.
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