Calreticulin

CALR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3POW, 2CLR, 3DOW, 3POS
Identifiers
Aliases	CALR, CRT, HEL-S-99n, RO, SSA, cC1qR, calreticulin
External IDs	OMIM: 109091 MGI: 88252 HomoloGene: 37911 GeneCards: CALR
Gene ontology Molecular function • calcium ion binding • protein binding involved in protein folding • glycoprotein binding • carbohydrate binding • hormone binding • metal ion binding • complement component C1q binding • mRNA binding • iron ion binding • unfolded protein binding • zinc ion binding • integrin binding • protein binding • DNA binding • chaperone binding • peptide binding • androgen receptor binding • ubiquitin protein ligase binding • RNA binding Cellular component • cytoplasm • cytosol • endoplasmic reticulum lumen • membrane • focal adhesion • extracellular region • perinuclear region of cytoplasm • sarcoplasmic reticulum lumen • nucleus • endocytic vesicle lumen • cell surface • endoplasmic reticulum • extracellular exosome • Golgi apparatus • intracellular membrane-bounded organelle • extracellular matrix • proteinaceous extracellular matrix • intracellular • protein complex • integral component of lumenal side of endoplasmic reticulum membrane • sarcoplasmic reticulum • smooth endoplasmic reticulum • MHC class I peptide loading complex • acrosomal vesicle • external side of plasma membrane • extracellular space • polysome • phagocytic vesicle membrane • endoplasmic reticulum-Golgi intermediate compartment membrane Biological process • negative regulation of neuron differentiation • protein folding in endoplasmic reticulum • receptor-mediated endocytosis • response to organic substance • cellular senescence • spermatogenesis • positive regulation of dendritic cell chemotaxis • regulation of apoptotic process • cellular response to organic substance • positive regulation of phagocytosis • negative regulation of intracellular steroid hormone receptor signaling pathway • regulation of transcription, DNA-templated • negative regulation of retinoic acid receptor signaling pathway • cardiac muscle cell differentiation • regulation of meiotic nuclear division • protein maturation by protein folding • positive regulation of cell cycle • protein export from nucleus • cellular response to lithium ion • peptide antigen assembly with MHC class I protein complex • antigen processing and presentation of peptide antigen via MHC class I • protein stabilization • cellular calcium ion homeostasis • negative regulation of transcription from RNA polymerase II promoter • positive regulation of DNA replication • protein folding • negative regulation of transcription, DNA-templated • cortical actin cytoskeleton organization • chaperone-mediated protein folding • response to estradiol • response to testosterone • ATF6-mediated unfolded protein response • positive regulation of substrate adhesion-dependent cell spreading • sequestering of calcium ion • positive regulation of gene expression • positive regulation of cell proliferation • protein localization to nucleus • response to drug • glucocorticoid receptor signaling pathway • positive regulation of NIK/NF-kappaB signaling • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • negative regulation of translation • negative regulation of cell cycle arrest • vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	811	12317
Ensembl	ENSG00000179218	ENSMUSG00000003814
UniProt	P27797	P14211
RefSeq (mRNA)	NM_004343	NM_007591
RefSeq (protein)	NP_004334	NP_031617.1 NP_031617
Location (UCSC)	Chr 19: 12.94 – 12.94 Mb	Chr 8: 84.84 – 84.85 Mb
PubMed search

3POW, 2CLR, 3DOW, 3POS

811

12317

ENSG00000179218

ENSMUSG00000003814

P27797

P14211

NM_004343

NM_007591

NP_004334

NP_031617.1
NP_031617

Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the CALR gene.

Calreticulin is a multifunctional protein that binds Ca²⁺ ions (a second messenger in signal transduction), rendering it inactive. The Ca²⁺ is bound with low affinity, but high capacity, and can be released on a signal (see inositol triphosphate). Calreticulin is located in storage compartments associated with the endoplasmic reticulum.

...
Wikipedia