Calnexin

CANX

Identifiers

CANX, CNX, IP90, P90, calnexin

External IDs

Gene ontology
Molecular function	• calcium ion binding • apolipoprotein binding • unfolded protein binding • glycoprotein binding • metal ion binding • protein binding • ionotropic glutamate receptor binding • carbohydrate binding • RNA binding
Cellular component	• cytoplasm • integral component of membrane • ER-mitochondrion membrane contact site • rough endoplasmic reticulum • ribosome • endoplasmic reticulum lumen • endoplasmic reticulum membrane • membrane • melanosome • myelin sheath • dendritic spine • smooth endoplasmic reticulum • protein complex • axon • neuronal cell body • endoplasmic reticulum • dendrite cytoplasm • integral component of lumenal side of endoplasmic reticulum membrane • extracellular exosome • extracellular matrix
Biological process	• antigen processing and presentation of exogenous peptide antigen via MHC class II • antigen processing and presentation of peptide antigen via MHC class I • aging • protein folding in endoplasmic reticulum • protein secretion • clathrin-dependent endocytosis • synaptic vesicle endocytosis • protein folding • chaperone-mediated protein folding
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


821


12330


ENSG00000127022


ENSMUSG00000020368


P27824


P35564

RefSeq (mRNA)


NM_001024649 NM_001746


NM_001110499 NM_001110500 NM_007597

RefSeq (protein)


NP_001019820 NP_001737

NP_001103969.1 NP_001103970.1 NP_031623.1 NP_001103969 NP_001103970
NP_031623

Location (UCSC)

PubMed search

Calnexin (CNX) is a 67kDa integral protein (that appears variously as a 90kDa, 80kDa, or 75kDa band on western blotting depending on the source of the antibody) of the endoplasmic reticulum (ER). It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail.