"Call on Me" is a song by American singer Janet Jackson with guest vocals from American rapper Nelly from Jackson's ninth studio album, 20 Y.O. (2006). It was written by Jermaine Dupri, Johnta Austin, James Phillips, Cornell Haynes, Jr., James Harris III and Terry Lewis, and produced by Dupri, Phillips, Jam and Lewis, in addition to Jackson. "Call on Me" was released as the album's lead single in June 19, 2006, by Virgin Records. It is a mid-tempo ballad which talks about calling on a person when a friend or somebody to listen is needed. The song received mixed reviews from music critics, although some picked it as one of the best tracks on the album, calling it a "lovely and elegant" ballad.

"Call on Me" was a moderate success commercially, becoming her most successful single in some countries since "All for You" in 2001. It peaked at number 25 on the US Billboard Hot 100. Additionally, it spent two non-consecutive weeks at number one on the Hot R&B/Hip-Hop Songs chart, making it Jackson's sixteenth R&B chart-topper. Internationally, the song peaked inside the top-twenty in Ireland, Italy, New Zealand and the United Kingdom.

The accompanying music video for "Call on Me" was directed by Hype Williams and took ten days to be completed. It incorporates Indian, Asian, and African styles, with a mixture of outfits and hairstyles. Outfits worn in the video included a specially-designed Kimono, metal corset, and nine-inch platform heels. "Call on Me" is one of the most expensive music videos of all time, with a production cost of over $1,000,000 (US). Following its release, it was reported that the video was blacklisted by MTV, following her incident at the Super Bowl halftime show in 2004, which was co-produced by the network.

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