Caenophrurium (also written as Cænophrurium, Cenophrurium and Coenophrurium; Greek: Καινοφρούριον, Kainophrourion) was a settlement in the Roman province of Europa (the southeasternmost part of Thrace), between Byzantium and Heraclea Perinthus. It appears in late Roman and early Byzantine accounts. Caenophrurium translates as the "stronghold of the Caeni", a Thracian tribe.
Classical scholars have at times identified various towns in Thrace as corresponding to Caenophrurium. Recent scholarship locates Caenophrurium near the modern Turkish village of Sinekli, in Silivri district, Istanbul Province.
The Barrington Atlas includes Caenophrurium as one of 24 komes (towns) and choria (villages) in the province of Europa. These were smaller settlements than the 14 cities of the province listed by Hierocles in his Synecdemus (c. 527–528): the provincial capital (Heraclea Perinthus) and 13 others.
Some confusion as to the exact location of Caenophrurium appears to derive from the fact that references to the settlement are all made in passing, either as a waystation between other towns, or as the location for the murder of the Emperor Aurelian. These original sources are:
Several routes in the Antonine Itinerary list Caenophrurium as a stage on the Via Egnatia, 18 miles east of Heraclea Perinthus and 27 or 28 miles east of Melantias (probably modern Yarımburgaz). Logically, this might place Caenophrurium on the Marmara coast near Silivri. Instead, it appears that Caenophrurium was actually sited inland, 20 kilometres (12 mi) to the north of the main Via Egnatia, on a smaller northern route from Byzantium to Bizye.