CYP4F8

CYP4F8
Identifiers
Aliases	CYP4F8, CPF8, CYPIVF8, cytochrome P450 family 4 subfamily F member 8
External IDs	MGI: 2146921 HomoloGene: 80199 GeneCards: CYP4F8
Gene ontology Molecular function • iron ion binding • oxidoreductase activity • aromatase activity • alkane 1-monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • metal ion binding • monooxygenase activity • oxygen binding Cellular component • integral component of membrane • organelle membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • intracellular membrane-bounded organelle Biological process • prostaglandin metabolic process • icosanoid metabolic process • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11283	106648
Ensembl	ENSG00000186526	ENSMUSG00000073424
UniProt	P98187	n/a
RefSeq (mRNA)	NM_007253	NM_134127 NM_001346538
RefSeq (protein)	NP_009184	n/a
Location (UCSC)	Chr 19: 15.62 – 15.63 Mb	Chr 17: 32.69 – 32.7 Mb
PubMed search

11283

106648

ENSG00000186526

ENSMUSG00000073424

P98187

n/a

NM_007253

NM_134127
NM_001346538

NP_009184

n/a

Cytochrome P450 4F8 is a protein that in humans is encoded by the CYP4F8 gene.

This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of the arachidonic acid metabolite, prostaglandin H2 (PGH2) and the Dihomo-γ-linolenic acid metabolite PGH1 in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. In addition to seminal vesicles, CYP4F8 is expressed in kidney, prostate, epidermis, and corneal epithelium, and its mRNA has been found in retina; CYP4F8 is also greatly up-regulated in psoriatic skin.

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Wikipedia