CYP2J2

CYP2J2
Identifiers
Aliases	CYP2J2, CPJ2, CYPIIJ2, cytochrome P450 family 2 subfamily J member 2
External IDs	MGI: 1270148 HomoloGene: 68091 GeneCards: CYP2J2
Gene ontology Molecular function • iron ion binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • metal ion binding • arachidonic acid 14,15-epoxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • arachidonic acid 11,12-epoxygenase activity • oxidoreductase activity • aromatase activity • linoleic acid epoxygenase activity • monooxygenase activity • arachidonic acid epoxygenase activity Cellular component • organelle membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum • extracellular exosome Biological process • linoleic acid metabolic process • regulation of heart contraction • epoxygenase P450 pathway • icosanoid metabolic process • xenobiotic metabolic process • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1573	13110
Ensembl	ENSG00000134716	ENSMUSG00000052914
UniProt	P51589	O54750
RefSeq (mRNA)	NM_000775	NM_010008
RefSeq (protein)	NP_000766	NP_034138.3 NP_034138
Location (UCSC)	Chr 1: 59.89 – 59.93 Mb	Chr 4: 96.52 – 96.55 Mb
PubMed search

1573

13110

ENSG00000134716

ENSMUSG00000052914

P51589

O54750

NM_000775

NM_010008

NP_000766

NP_034138.3
NP_034138

Cytochrome P450 2J2 (CYP2J2) is a protein that in humans is encoded by the CYP2J2 gene. CYP2J2 is a member of the cytochrome P450 superfamily of enzymes. The enzymes are oxygenases which catalyze many reactions involved in the metabolism of drugs and other xenobiotics) as well as in the synthesis of cholesterol, steroids and other lipids.

CYP2J2 localizes to the endoplasmic reticulum and is thought to be a prominent enzyme responsible for metabolizing endogenous polyunsaturated fatty acids to signaling molecules. It metabolizes arachidonic acid to the following eicosatrienoic acid epoxides (termed EETs): 5,6-epoxy-8Z,11Z,14Z-EET, 5,6-epoxy-8Z,11Z,14Z-EET, 11,12-epoxy-5Z,8Z,14Z-EET, and 14,15-epoxy-5Z,8Z,11Z-EET. CYP2J2 also metabolizes linoleic acid to 9,10-epoxy octadecaenoic acids (also termed vernolic acid, linoleic acid 9:10-oxide, or leukotoxin) and 12,13-epoxy-octadecaenoic (also termed coronaric acid, linoleic acid 12,13-oxide, or isoleukotoxin); docosahexaenoic acid to various epoxydocosapentaenoic acids (also termed EDPs); and eicosapentaenoic acid to various epoxyeicosatetraenoic acids (also termed EEQs).

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