CYP2F1

CYP2F1
Identifiers
Aliases	CYP2F1, C2F1, CYP2F, CYPIIF1, cytochrome P450 family 2 subfamily F member 1
External IDs	MGI: 88608 HomoloGene: 73898 GeneCards: CYP2F1
Gene ontology Molecular function • iron ion binding • oxygen binding • arachidonic acid epoxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • aromatase activity • steroid hydroxylase activity Cellular component • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • membrane • endoplasmic reticulum Biological process • epoxygenase P450 pathway • trichloroethylene metabolic process • naphthalene metabolic process • xenobiotic metabolic process • oxidation-reduction process • response to toxic substance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1572	13107
Ensembl	ENSG00000197446	ENSMUSG00000052974
UniProt	P24903	P33267
RefSeq (mRNA)	NM_000774	NM_007817
RefSeq (protein)	NP_000765	NP_031843
Location (UCSC)	Chr 19: 41.11 – 41.13 Mb	Chr 7: 27.12 – 27.13 Mb
PubMed search

1572

13107

ENSG00000197446

ENSMUSG00000052974

P24903

P33267

NM_000774

NM_007817

NP_000765

NP_031843

Cytochrome P450 2F1 is a protein that in humans is encoded by the CYP2F1 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates, such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

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