CYP2E1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3E4E, 3E6I, 3GPH, 3KOH, 3LC4, 3T3Z

Identifiers

Aliases

CYP2E1, CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 family 2 subfamily E member 1

External IDs

OMIM: 124040 MGI: 88607 HomoloGene: 68089 GeneCards: CYP2E1

EC number

1.14.13.n7

Genetically Related Diseases

obesity

Gene ontology
Molecular function	• iron ion binding • oxygen binding • arachidonic acid epoxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • enzyme binding • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
Cellular component	• organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • membrane • intrinsic component of endoplasmic reticulum membrane • Golgi membrane • endoplasmic reticulum • mitochondrion
Biological process	• steroid metabolic process • epoxygenase P450 pathway • response to ozone • heterocycle metabolic process • response to organonitrogen compound • monoterpenoid metabolic process • xenobiotic metabolic process • response to ethanol • oxidation-reduction process • triglyceride metabolic process • response to drug • carbon tetrachloride metabolic process • drug metabolic process • halogenated hydrocarbon metabolic process • benzene metabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1571


13106

Ensembl


ENSG00000130649


ENSMUSG00000025479

UniProt


P05181


Q05421

RefSeq (mRNA)


NM_000773


NM_021282

RefSeq (protein)


NP_000764


NP_067257.1 NP_067257

Location (UCSC)

Chr 10: 133.52 – 133.56 Mb

Chr 7: 140.76 – 140.77 Mb

PubMed search

3E4E, 3E6I, 3GPH, 3KOH, 3LC4, 3T3Z

NP_067257.1
NP_067257

Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown of foreign compounds in mammals.

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