CYP2C18

CYP2C18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CIK, 2H6P
Identifiers
Aliases	CYP2C18, CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17, cytochrome P450 family 2 subfamily C member 18
External IDs	MGI: 1919332 HomoloGene: 133567 GeneCards: CYP2C18
Gene ontology Molecular function • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • aromatase activity • iron ion binding • oxidoreductase activity • monooxygenase activity • heme binding • oxygen binding • arachidonic acid epoxygenase activity • metal ion binding • steroid hydroxylase activity Cellular component • endoplasmic reticulum membrane • organelle membrane • intracellular membrane-bounded organelle • membrane • endoplasmic reticulum Biological process • epoxygenase P450 pathway • xenobiotic metabolic process • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1562	72082
Ensembl	ENSG00000108242	ENSMUSG00000025002
UniProt	P33260	Q9D816
RefSeq (mRNA)	NM_001128925 NM_000772	NM_028089
RefSeq (protein)	NP_000763 NP_001122397	NP_082365
Location (UCSC)	Chr 10: 94.68 – 94.74 Mb	Chr 19: 39.01 – 39.04 Mb
PubMed search

2CIK, 2H6P

1562

72082

ENSG00000108242

ENSMUSG00000025002

P33260

Q9D816

NM_001128925
NM_000772

NM_028089

NP_000763
NP_001122397

NP_082365

Cytochrome P450 2C18 is a protein that in humans is encoded by the CYP2C18 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19.

CYP2C18 also possesses epoxygenase activitiy: it can attack various long-chain polyunsaturated fatty acids at their double (i.e. alkene) bonds to form epoxide products that act as signaling agents. It metabolizes: 1) arachidonic acid to various epoxyeicosatrienoic acids (also termed EETs); 2) linoleic acid to 9,10-epoxy octadecaenoic acids (also termed vernolic acid, linoleic acid 9:10-oxide, or leukotoxin) and 12,13-epoxy-octadecaenoic (also termed coronaric acid, linoleic acid 12,13-oxide, or isoleukotoxin); 3) docosohexaenoic acid to various epoxydocosapentaenoic acids (also termed EDPs); and 4) eicosapentaenoic acid to various epoxyeicosatetraenoic acids (also termed EEQs).

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