CYP2A13

CYP2A13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P85, 2PG5, 2PG6, 2PG7, 3T3S, 4EJG, 4EJH, 4EJI
Identifiers
Aliases	CYP2A13, CPAD, CYP2A, CYPIIA13, cytochrome P450 family 2 subfamily A member 13
External IDs	MGI: 88596 HomoloGene: 85917 GeneCards: CYP2A13
Gene ontology Molecular function • iron ion binding • oxidoreductase activity • aromatase activity • arachidonic acid epoxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • metal ion binding • monooxygenase activity • coumarin 7-hydroxylase activity • oxygen binding • steroid hydroxylase activity Cellular component • organelle membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • intracellular membrane-bounded organelle Biological process • xenobiotic metabolic process • epoxygenase P450 pathway • oxidation-reduction process • coumarin metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1553	13086
Ensembl	ENSG00000197838	ENSMUSG00000074254
UniProt	Q16696	P15392
RefSeq (mRNA)	NM_000766	NM_009997
RefSeq (protein)	NP_000757	NP_034127
Location (UCSC)	Chr 19: 41.09 – 41.1 Mb	Chr 7: 26.31 – 26.32 Mb
PubMed search

2P85, 2PG5, 2PG6, 2PG7, 3T3S, 4EJG, 4EJH, 4EJI

1553

13086

ENSG00000197838

ENSMUSG00000074254

Q16696

P15392

NM_000766

NM_009997

NP_000757

NP_034127

Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

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