CYP27A1

CYP27A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MFX
Identifiers
Aliases	CYP27A1, CP27, CTX, CYP27, cytochrome P450 family 27 subfamily A member 1
External IDs	OMIM: 606530 MGI: 88594 HomoloGene: 36040 GeneCards: CYP27A1
Gene ontology Molecular function • monooxygenase activity • iron ion binding • steroid hydroxylase activity • oxidoreductase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • metal ion binding Cellular component • mitochondrial inner membrane • mitochondrial matrix • membrane • mitochondrial membrane • mitochondrion Biological process • sterol metabolic process • bile acid biosynthetic process • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1593	104086
Ensembl	ENSG00000135929	ENSMUSG00000026170
UniProt	Q02318	Q9DBG1
RefSeq (mRNA)	NM_000784	NM_024264
RefSeq (protein)	NP_000775	NP_077226.2 NP_077226
Location (UCSC)	Chr 2: 218.78 – 218.82 Mb	Chr 1: 74.71 – 74.74 Mb
PubMed search

1MFX

1593

104086

ENSG00000135929

ENSMUSG00000026170

Q02318

Q9DBG1

NM_000784

NM_024264

NP_000775

NP_077226.2
NP_077226

CYP27A1 is a gene encoding a , and is commonly known as sterol 27-hydroxylase. This enzyme is located in many different tissues where it is found within the . It is most prominently involved in the biosynthesis of bile acids.

CYP27A1 participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways. It is the initiating enzyme in the acidic pathway to bile acids, yielding oxysterols by introducing a hydroxyl group to the carbon at the 27 position in cholesterol. In the acidic pathway, it produces 27-hydroxycholesterol from cholesterol whereas in the classic or neutral pathway, it produces 3β-hydroxy-5-cholestenoic acid.

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