CYP24A1

Identifiers

CYP24A1, CP24, CYP24, HCAI, P450-CC24, cytochrome P450 family 24 subfamily A member 1, HCINF1

External IDs

MGI: 88593 HomoloGene: 68094 GeneCards: CYP24A1

Gene ontology
Molecular function	• iron ion binding • 25-hydroxycholecalciferol-24-hydroxylase activity • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
Cellular component	• plasma membrane • nucleoplasm • mitochondrion • nucleus • mitochondrial outer membrane
Biological process	• response to vitamin D • vitamin D metabolic process • vitamin metabolic process • osteoblast differentiation • vitamin D catabolic process • vitamin D receptor signaling pathway • oxidation-reduction process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1591


13081

Ensembl


ENSG00000019186


ENSMUSG00000038567

UniProt


Q07973


Q64441

RefSeq (mRNA)


NM_000782 NM_001128915


NM_009996

RefSeq (protein)


NP_000773 NP_001122387


NP_034126

Location (UCSC)

Chr 20: 54.15 – 54.17 Mb

Chr 2: 170.48 – 170.5 Mb

PubMed search

NM_000782
NM_001128915

NM_009996

NP_000773
NP_001122387

NP_034126

1,25-dihydroxyvitamin D₃ 24-hydroxylase, mitochondrial is an enzyme that in humans is encoded by the CYP24A1 gene. Its expression is translationally regulated via IRES within the 5'UTR, which is responsive to an inflammatory environment.

This gene encodes a member of the superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D₃, the physiologically active form of vitamin D₃, by hydroxylation of the side chain to form calcitroic acid.

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