CYP1A1

CYP1A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4I8V
Identifiers
Aliases	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX, CYPIA1, cytochrome P450 family 1 subfamily A member 1
External IDs	OMIM: 108330 MGI: 88588 HomoloGene: 68062 GeneCards: CYP1A1
Gene location (Human) Chr. Chromosome 15 (human) Band No data available Start 74,719,542 bp End 74,725,610 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band No data available Start 57,687,928 bp End 57,703,824 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • iron ion binding • oxygen binding • flavonoid 3'-monooxygenase activity • demethylase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • metal ion binding • steroid hydroxylase activity • catalytic activity • protein binding • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • enzyme binding • vitamin D 24-hydroxylase activity • oxidoreductase activity • aromatase activity • oxidoreductase activity, acting on diphenols and related substances as donors • monooxygenase activity • estrogen 16-alpha-hydroxylase activity Cellular component • cytoplasm • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • membrane • endoplasmic reticulum • mitochondrion Biological process • response to immobilization stress • maternal process involved in parturition • response to hypoxia • 9-cis-retinoic acid biosynthetic process • response to organic cyclic compound • coumarin metabolic process • vitamin D metabolic process • insecticide metabolic process • response to hyperoxia • response to antibiotic • demethylation • cellular response to organic cyclic compound • response to virus • aging • hepatocyte differentiation • epoxygenase P450 pathway • dibenzo-p-dioxin catabolic process • developmental process • response to arsenic-containing substance • response to organic substance • positive regulation of G1/S transition of mitotic cell cycle • response to vitamin A • response to lipopolysaccharide • omega-hydroxylase P450 pathway • response to wounding • dibenzo-p-dioxin metabolic process • response to nematode • response to iron(III) ion • flavonoid metabolic process • response to food • drug metabolic process • liver development • camera-type eye development • digestive tract development • cell proliferation • oxidation-reduction process • response to herbicide • response to drug • porphyrin-containing compound metabolic process • ethylene metabolic process • lipid hydroxylation • steroid metabolic process • cellular response to copper ion • amine metabolic process • toxin metabolic process • response to toxic substance • regulation of lipid metabolic process • heterocycle metabolic process • hydrogen peroxide biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1543	13076
Ensembl	ENSG00000140465	ENSMUSG00000032315
UniProt	P04798	P00184
RefSeq (mRNA)	NM_000499 NM_001319216 NM_001319217	NM_001136059 NM_009992
RefSeq (protein)	NP_000490 NP_001306145 NP_001306146	NP_001129531 NP_034122
Location (UCSC)	Chr 15: 74.72 – 74.73 Mb	Chr 15: 57.69 – 57.7 Mb
PubMed search

4I8V

1543

13076

ENSG00000140465

ENSMUSG00000032315

P04798

P00184

NM_000499
NM_001319216
NM_001319217

NM_001136059
NM_009992

NP_000490
NP_001306145
NP_001306146

NP_001129531
NP_034122

Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the CYP1A1 gene. The protein is a member of the superfamily of enzymes.

CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline). It is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons.

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