CTCF

CTCF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X6H, 2CT1
Identifiers
Aliases	CTCF, MRD21, CCCTC-binding factor
External IDs	MGI: 109447 HomoloGene: 4786 GeneCards: CTCF
Gene ontology Molecular function • DNA binding • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • zinc ion binding • chromatin binding • metal ion binding • chromatin insulator sequence binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • nucleic acid binding • transcription regulatory region DNA binding • sequence-specific DNA binding Cellular component • nucleoplasm • chromosome • nucleolus • chromosome, centromeric region • condensed chromosome • nucleus Biological process • regulation of gene expression by genetic imprinting • regulation of transcription, DNA-templated • maintenance of DNA methylation • regulation of gene expression, epigenetic • regulation of centromeric sister chromatid cohesion • regulation of molecular function, epigenetic • chromosome segregation • nucleosome positioning • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of gene expression • transcription, DNA-templated • positive regulation of transcription, DNA-templated • DNA methylation • regulation of histone methylation • positive regulation of gene expression • regulation of histone acetylation • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • covalent chromatin modification • protein localization to chromosome, centromeric region Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10664	13018
Ensembl	ENSG00000102974	ENSMUSG00000005698
UniProt	P49711	Q61164
RefSeq (mRNA)	NM_001191022 NM_006565	NM_181322
RefSeq (protein)	NP_001177951 NP_006556	NP_851839
Location (UCSC)	Chr 16: 67.56 – 67.64 Mb	Chr 8: 105.64 – 105.68 Mb
PubMed search

1X6H, 2CT1

10664

13018

ENSG00000102974

ENSMUSG00000005698

P49711

Q61164

NM_001191022
NM_006565

NM_181322

NP_001177951
NP_006556

NP_851839

Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of chromatin architecture.

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