CSPG4

Identifiers

CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2, chondroitin sulfate proteoglycan 4

External IDs

MGI: 2153093 HomoloGene: 20445 GeneCards: CSPG4

Gene ontology
Molecular function	• signal transducer activity • protein kinase binding
Cellular component	• integral component of membrane • cell projection • membrane • focal adhesion • plasma membrane • integral component of plasma membrane • extracellular region • cell surface • lysosomal lumen • apical plasma membrane • Golgi lumen • extracellular exosome • lamellipodium membrane
Biological process	• glycosaminoglycan metabolic process • cell differentiation • intracellular signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • chondroitin sulfate biosynthetic process • multicellular organism development • activation of MAPK activity • angiogenesis • positive regulation of peptidyl-tyrosine phosphorylation • chondroitin sulfate catabolic process • dermatan sulfate biosynthetic process • cell proliferation • tissue remodeling • signal transduction • glial cell migration
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1464


121021

Ensembl


ENSG00000173546


ENSMUSG00000032911

UniProt


Q6UVK1


Q8VHY0

RefSeq (mRNA)


NM_001897


NM_139001

RefSeq (protein)


NP_001888


NP_620570.2 NP_620570

Location (UCSC)

Chr 15: 75.67 – 75.71 Mb

Chr 9: 56.87 – 56.9 Mb

PubMed search

NP_620570.2
NP_620570

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.

CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.

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