CSF1R

CSF1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM
Identifiers
Aliases	CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor
External IDs	MGI: 1339758 HomoloGene: 3817 GeneCards: CSF1R
EC number	2.7.10.1
Targeted by Drug
cediranib, crenolanib, linifanib, pazopanib
Gene ontology Molecular function • nucleotide binding • protein tyrosine kinase activity • protein kinase activity • transferase activity • transmembrane receptor protein tyrosine kinase activity • kinase activity • protein homodimerization activity • ATP binding • protein phosphatase binding • macrophage colony-stimulating factor receptor activity • cytokine binding Cellular component • integral component of membrane • integral component of plasma membrane • membrane • cell surface • CSF1-CSF1R complex • nucleoplasm • plasma membrane • intracellular membrane-bounded organelle Biological process • negative regulation of cell proliferation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of protein serine/threonine kinase activity • mammary gland duct morphogenesis • positive regulation of cell motility • macrophage colony-stimulating factor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of chemokine secretion • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • signal transduction • axon guidance • multicellular organism development • monocyte differentiation • macrophage differentiation • ruffle organization • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of cell migration • cellular response to cytokine stimulus • protein autophosphorylation • hemopoiesis • peptidyl-tyrosine phosphorylation • olfactory bulb development • regulation of bone resorption • phosphatidylinositol metabolic process • protein phosphorylation • positive regulation of protein tyrosine kinase activity • cell-cell junction maintenance • osteoclast differentiation • innate immune response • regulation of actin cytoskeleton reorganization • immune system process • inflammatory response • positive regulation of protein phosphorylation • forebrain neuron differentiation • phosphorylation • cytokine-mediated signaling pathway • cellular response to macrophage colony-stimulating factor stimulus • positive regulation of cell proliferation • regulation of cell shape • cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1436	12978
Ensembl	ENSG00000182578	ENSMUSG00000024621
UniProt	P07333	P09581
RefSeq (mRNA)	NM_001288705 NM_005211	NM_001037859 NM_007779
RefSeq (protein)	NP_001275634 NP_005202	NP_001032948.2 NP_001032948
Location (UCSC)	Chr 5: 150.05 – 150.11 Mb	Chr 18: 61.11 – 61.13 Mb
PubMed search

2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM

1436

12978

ENSG00000182578

ENSMUSG00000024621

P07333

P09581

NM_001288705
NM_005211

...
Wikipedia