CREB1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2LXT

Identifiers

Aliases

CREB1, CREB, CREB-1, cAMP responsive element binding protein 1

External IDs

MGI: 88494 HomoloGene: 3223 GeneCards: CREB1

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II activating transcription factor binding • transcription regulatory region DNA binding • arrestin family protein binding • cAMP response element binding • transcription factor binding • transcription cofactor activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • Hsp70 protein binding • enzyme binding • RNA polymerase II distal enhancer sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription factor binding • protein binding • histone acetyltransferase binding • double-stranded DNA binding • DNA binding • sequence-specific DNA binding • regulatory region DNA binding • identical protein binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • RNA polymerase II transcription coactivator binding
Cellular component	• mitochondrion • nucleus • ATF4-CREB1 transcription factor complex • nuclear chromatin • chromatin • transcription factor complex • nucleoplasm • axon • mitochondrial matrix • nuclear euchromatin
Biological process	• cellular response to nerve growth factor stimulus • positive regulation of lipid biosynthetic process • positive regulation of long-term synaptic potentiation • rhythmic process • cellular response to insulin-like growth factor stimulus • transcription from RNA polymerase II promoter • response to organic substance • mammary gland development • protein phosphorylation • Type I pneumocyte differentiation • circadian rhythm • positive regulation of multicellular organism growth • response to L-glutamate • lung saccule development • lung epithelium development • transforming growth factor beta receptor signaling pathway • regulation of apoptotic process • cellular response to transforming growth factor beta stimulus • response to glucagon • regulation of transcription, DNA-templated • negative regulation of transcription by competitive promoter binding • response to nicotine • positive regulation of osteoclast differentiation • memory • negative regulation of gene expression • transcription, DNA-templated • positive regulation of transcription, DNA-templated • lactation • positive regulation of transforming growth factor beta3 production • viral process • positive regulation of fat cell differentiation • negative regulation of neuron death • cell differentiation • cellular response to hepatocyte growth factor stimulus • protein stabilization • cellular response to platelet-derived growth factor stimulus • regulation of circadian rhythm • secretory granule organization • regulation of glial cell proliferation • visual learning • regulation of cell size • pituitary gland development • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly • response to hypoxia • axonogenesis • regulation of fibroblast proliferation • cellular response to growth factor stimulus • aging • chemotaxis to arachidonic acid • response to activity • cellular response to zinc ion • axon guidance • cellular response to fatty acid • positive regulation of apoptotic process • positive regulation of hormone secretion • response to drug • signal transduction • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cardiac muscle tissue development
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1385


12912

Ensembl


ENSG00000118260


ENSMUSG00000025958

UniProt


P16220


Q01147

RefSeq (mRNA)


NM_004379 NM_134442 NM_001320793


NM_001037726 NM_009952 NM_133828

RefSeq (protein)


NP_001307722 NP_004370 NP_604391


NP_034082.1 NP_598589.2 NP_001032815 NP_034082 NP_598589

Location (UCSC)

Chr 2: 207.53 – 207.6 Mb

Chr 1: 64.53 – 64.6 Mb

PubMed search

NM_004379
NM_134442
NM_001320793

NM_001037726
NM_009952
NM_133828

NP_001307722
NP_004370
NP_604391

NP_034082.1
NP_598589.2
NP_001032815
NP_034082
NP_598589

...
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