COL1A1

COL1A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GXE, 1Q7D, 2LLP, 3EJH
Identifiers
Aliases	COL1A1, EDSC, OI1, OI2, OI3, OI4, collagen type I alpha 1
External IDs	OMIM: 120150 MGI: 88467 HomoloGene: 73874 GeneCards: COL1A1
Gene ontology Molecular function • metal ion binding • identical protein binding • platelet-derived growth factor binding • extracellular matrix structural constituent • protein binding Cellular component • extracellular region • endoplasmic reticulum lumen • cytoplasm • proteinaceous extracellular matrix • Golgi apparatus • endoplasmic reticulum • collagen trimer • secretory granule • extracellular matrix • collagen type I trimer • extracellular space Biological process • cellular response to tumor necrosis factor • blood coagulation • tooth eruption • response to mechanical stimulus • response to corticosteroid • negative regulation of cell-substrate adhesion • response to steroid hormone • extracellular matrix organization • osteoblast differentiation • collagen fibril organization • skin morphogenesis • bone trabecula formation • wound healing • skin development • intramembranous ossification • positive regulation of cell migration • tooth mineralization • cellular response to epidermal growth factor stimulus • cellular response to fibroblast growth factor stimulus • response to estradiol • collagen catabolic process • response to cAMP • cellular response to vitamin E • response to fluoride • cartilage development involved in endochondral bone morphogenesis • sensory perception of sound • response to peptide hormone • cellular response to retinoic acid • cellular response to transforming growth factor beta stimulus • regulation of immune response • cellular response to fluoride • positive regulation of transcription, DNA-templated • leukocyte migration • collagen biosynthetic process • protein heterotrimerization • cellular response to amino acid stimulus • endochondral ossification • response to hyperoxia • face morphogenesis • protein transport • response to nutrient • response to drug • platelet activation • visual perception • positive regulation of epithelial to mesenchymal transition • response to hydrogen peroxide • embryonic skeletal system development • skeletal system morphogenesis • ossification • response to nutrient levels • positive regulation of canonical Wnt signaling pathway • protein localization to nucleus • cellular response to mechanical stimulus • skeletal system development • blood vessel development • collagen-activated tyrosine kinase receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1277	12842
Ensembl	ENSG00000108821	ENSMUSG00000001506
UniProt	P02452	P11087
RefSeq (mRNA)	NM_000088	NM_007742
RefSeq (protein)	NP_000079	NP_031768.2 NP_031768
Location (UCSC)	Chr 17: 50.18 – 50.2 Mb	Chr 11: 94.94 – 94.95 Mb
PubMed search

3GXE, 1Q7D, 2LLP, 3EJH

1277

12842

ENSG00000108821

ENSMUSG00000001506

P02452

P11087

NM_000088

NM_007742

NP_000079

NP_031768.2
NP_031768

Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage.

Collagen is a protein that strengthens and supports many tissues in the body, including cartilage, bone, tendon, skin and the white part of the eye (sclera). The COL1A1 gene produces a component of type I collagen, called the pro-alpha1(I) chain. This chain combines with another pro-alpha1(I) chain and also with a pro-alpha2(I) chain (produced by the COL1A2 gene) to make a molecule of type I procollagen. These triple-stranded, rope-like procollagen molecules must be processed by enzymes outside the cell. Once these molecules are processed, they arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong mature type I collagen fibers. Collagenous function includes rigidity and elasticity.

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Wikipedia