CLC (gene)

CLC
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1G86, 1HDK, 1LCL, 1QKQ
Identifiers
Aliases	CLC, GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN, Charcot-Leyden crystal galectin
External IDs	HomoloGene: 130498 GeneCards: CLC
Gene location (Human) Chr. Chromosome 19 (human) Band No data available Start 39,731,250 bp End 39,738,028 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cysteine-type endopeptidase activity involved in apoptotic process • lysophospholipase activity • protein binding • carbohydrate binding • identical protein binding Cellular component • cytoplasm • cytosol Biological process • multicellular organism development • T cell apoptotic process • regulation of T cell cytokine production • regulation of activated T cell proliferation • regulation of T cell anergy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1178	n/a
Ensembl	ENSG00000105205	n/a
UniProt	Q05315	n/a
RefSeq (mRNA)	NM_001828	n/a
RefSeq (protein)	NP_001819	n/a
Location (UCSC)	Chr 19: 39.73 – 39.74 Mb	n/a
PubMed search		n/a

1G86, 1HDK, 1LCL, 1QKQ

1178

n/a

ENSG00000105205

n/a

Q05315

n/a

NM_001828

n/a

NP_001819

n/a

Eosinophil lysophospholipase is an enzyme that in humans is encoded by the CLC gene.

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.

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