CK6

KRT6A
Identifiers
Aliases	KRT6A, CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3, CK-6C, CK-6E, keratin 6A
External IDs	OMIM: 148041 HomoloGene: 36182 GeneCards: KRT6A
Gene ontology Molecular function • structural constituent of cytoskeleton • protein binding • structural molecule activity Cellular component • keratin filament • extracellular exosome • intermediate filament • membrane • nucleus • cytosol Biological process • morphogenesis of an epithelium • cell differentiation • wound healing • positive regulation of cell proliferation • cytoskeleton organization • keratinization • cornification • negative regulation of cytolysis by symbiont of host cells • defense response to Gram-positive bacterium • cytolysis in other organism involved in symbiotic interaction • antimicrobial humoral immune response mediated by antimicrobial peptide • negative regulation of entry of bacterium into host cell Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3853	n/a
Ensembl	ENSG00000205420	n/a
UniProt	P02538	n/a
RefSeq (mRNA)	NM_005554	n/a
RefSeq (protein)	NP_005545	n/a
Location (UCSC)	Chr 12: 52.49 – 52.49 Mb	n/a
PubMed search		n/a

3853

n/a

ENSG00000205420

n/a

P02538

n/a

NM_005554

n/a

NP_005545

n/a

Keratin 6A is one of the 27 different type II keratins expressed in humans. Keratin 6A was the first type II keratin sequence determined. Analysis of the sequence of this keratin together with that of the first type I keratin led to the discovery of the four helical domains in the central rod of keratins. In humans Keratin 6A is encoded by the KRT6A gene.

Keratins are the intermediate filament proteins that form a dense meshwork of filaments throughout the cytoplasm of epithelial cells. Keratins form heteropolymers consisting of a type I and a type II keratin. Keratins are generally expressed in particular pairs of type I and type II keratin proteins in a tissue-specific and cellular differentiation-specific manner.

The keratin proteins of epithelial tissues are commonly known as "keratins" or are sometimes referred to as "epithelial keratins" or "cytokeratins". The specialized keratins of hair and nail are known as "hard keratins" or "trichocyte keratins". Trichocytes are the specialized epithelial cells from which hair and nail are composed. Trichocyte keratins are similar in their gene and protein structure to keratins except that they are especially rich in the sulfur-containing amino acid cysteine, which facilitates chemical cross-linking of the assembled hard keratins to form a more structurally resilient material.

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Wikipedia