CHRNB2

CHRNB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K58, 2K59, 2KSR, 2LM2
Identifiers
Aliases	CHRNB2, EFNL3, nAChRB2, cholinergic receptor nicotinic beta 2 subunit
External IDs	MGI: 87891 HomoloGene: 595 GeneCards: CHRNB2
Gene ontology Molecular function • acetylcholine binding • acetylcholine receptor activity • ion channel activity • protein binding • drug binding • ligand-gated ion channel activity • protein heterodimerization activity • extracellular ligand-gated ion channel activity • acetylcholine-gated cation-selective channel activity Cellular component • acetylcholine-gated channel complex • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • synapse • cell junction • external side of plasma membrane Biological process • visual learning • regulation of synaptic transmission, dopaminergic • response to cocaine • smooth muscle contraction • regulation of circadian sleep/wake cycle, REM sleep • regulation of dopamine secretion • response to hypoxia • associative learning • cognition • locomotory behavior • protein heterooligomerization • central nervous system neuron axonogenesis • optic nerve morphogenesis • regulation of synapse assembly • regulation of membrane potential • response to nicotine • membrane depolarization • neurological system process • synaptic transmission, cholinergic • ion transport • sensory perception of sound • learning • memory • negative regulation of action potential • regulation of dopamine metabolic process • behavioral response to nicotine • regulation of dendrite morphogenesis • B cell activation • neuromuscular synaptic transmission • synaptic transmission involved in micturition • positive regulation of dopamine secretion • positive regulation of B cell proliferation • regulation of circadian sleep/wake cycle, non-REM sleep • vestibulocochlear nerve development • conditioned taste aversion • transport • social behavior • action potential • sensory perception of pain • lateral geniculate nucleus development • positive regulation of synaptic transmission, dopaminergic • response to ethanol • central nervous system projection neuron axonogenesis • calcium ion transport • signal transduction • visual perception • ion transmembrane transport • regulation of postsynaptic membrane potential • excitatory postsynaptic potential • acetylcholine receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1141	11444
Ensembl	ENSG00000160716	ENSMUSG00000027950
UniProt	P17787	Q9ERK7
RefSeq (mRNA)	NM_000748	NM_009602
RefSeq (protein)	NP_000739	NP_033732.2 NP_033732
Location (UCSC)	Chr 1: 154.57 – 154.58 Mb	Chr 3: 89.75 – 89.76 Mb
PubMed search

2K58, 2K59, 2KSR, 2LM2

1141

11444

ENSG00000160716

ENSMUSG00000027950

P17787

Q9ERK7

NM_000748

NM_009602

NP_000739

NP_033732.2
NP_033732

Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene.

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.

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