CHKB (gene)

CHKB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FEG, 2IG7, 3LQ3
Identifiers
Aliases	CHKB, CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC, choline kinase beta
External IDs	MGI: 1328313 HomoloGene: 88718 GeneCards: CHKB
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.33 Start 50,578,949 bp End 50,601,455 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E3 Start 89,416,405 bp End 89,429,908 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • ATP binding • kinase activity • choline kinase activity • ethanolamine kinase activity Cellular component • cytosol Biological process • phosphatidylcholine biosynthetic process • phosphatidylethanolamine biosynthetic process • phosphorylation • lipid metabolic process • phospholipid biosynthetic process • glycerophospholipid biosynthetic process • CDP-choline pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1120	12651
Ensembl	ENSG00000100288	ENSMUSG00000022617
UniProt	Q9Y259	O55229
RefSeq (mRNA)	NM_152253 NM_005198	NM_007692
RefSeq (protein)	NP_005189	NP_031718
Location (UCSC)	Chr 22: 50.58 – 50.6 Mb	Chr 22: 89.42 – 89.43 Mb
PubMed search

3FEG, 2IG7, 3LQ3

1120

12651

ENSG00000100288

ENSMUSG00000022617

Q9Y259

O55229

NM_152253
NM_005198

NM_007692

NP_005189

NP_031718

Choline kinase beta is a protein encoded by the CHKB gene. This gene is found on chromosome 22 in humans.

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.

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Wikipedia