CHK2

CHEK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GXC, 2CN5, 2CN8, 2W0J, 2W7X, 2WTC, 2WTD, 2XBJ, 2XM8, 2XM9, 2YCF, 2YCQ, 2YCR, 2YCS, 2YIQ, 2YIR, 2YIT, 3I6U, 3I6W, 4A9R, 4A9S, 4A9T, 4A9U, 4BDA, 4BDB, 4BDC, 4BDD, 4BDE, 4BDF, 4BDG, 4BDH, 4BDI, 4BDJ, 4BDK, 2WTI, 2WTJ, 2XK9
Identifiers
Aliases	CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 2
External IDs	OMIM: 604373 MGI: 1355321 HomoloGene: 38289 GeneCards: CHEK2
Gene location (Human) Chr. Chromosome 22 (human) Band No data available Start 28,687,743 bp End 28,742,422 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band No data available Start 110,839,979 bp End 110,874,145 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • metal ion binding • protein serine/threonine kinase activity • protein binding • identical protein binding • protein kinase binding • ATP binding • ubiquitin protein ligase binding • kinase activity Cellular component • PML body • Golgi apparatus • nucleoplasm • chromosome, telomeric region • nucleus Biological process • positive regulation of protein phosphorylation • regulation of transcription, DNA-templated • cellular response to bisphenol A • negative regulation of DNA damage checkpoint • phosphorylation • signal transduction in response to DNA damage • replicative senescence • DNA damage checkpoint • protein stabilization • cellular protein catabolic process • transcription, DNA-templated • replicative cell aging • cellular response to DNA damage stimulus • cell division • negative regulation of cell cycle arrest • positive regulation of transcription, DNA-templated • protein phosphorylation • mitotic spindle assembly • cellular response to drug • G2/M transition of mitotic cell cycle • intrinsic apoptotic signaling pathway in response to DNA damage • DNA damage induced protein phosphorylation • regulation of protein catabolic process • protein autophosphorylation • cell cycle • positive regulation of anoikis • response to gamma radiation • signal transduction involved in intra-S DNA damage checkpoint • apoptotic process • double-strand break repair • DNA repair • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • regulation of signal transduction by p53 class mediator • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of apoptotic process • cellular response to gamma radiation • response to glycoside Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11200	50883
Ensembl	ENSG00000183765	ENSMUSG00000029521
UniProt	O96017	Q9Z265
RefSeq (mRNA)	NM_001005735 NM_001257387 NM_007194 NM_145862 NM_001349956	NM_016681
RefSeq (protein)	NP_001005735 NP_001244316 NP_009125 NP_665861 NP_001336885	NP_057890
Location (UCSC)	Chr 22: 28.69 – 28.74 Mb	Chr 22: 110.84 – 110.87 Mb
PubMed search

1GXC, 2CN5, 2CN8, 2W0J, 2W7X, 2WTC, 2WTD, 2XBJ, 2XM8, 2XM9, 2YCF, 2YCQ, 2YCR, 2YCS, 2YIQ, 2YIR, 2YIT, 3I6U, 3I6W, 4A9R, 4A9S, 4A9T, 4A9U, 4BDA, 4BDB, 4BDC, 4BDD, 4BDE, 4BDF, 4BDG, 4BDH, 4BDI, 4BDJ, 4BDK, 2WTI, 2WTJ, 2XK9

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