CHD3

CHD3
Identifiers
Aliases	CHD3, Mi-2a, Mi2-ALPHA, ZFH, chromodomain helicase DNA binding protein 3
External IDs	MGI: 1344395 HomoloGene: 62693 GeneCards: CHD3
Gene ontology Molecular function • metal ion binding • nucleotide binding • ATP-dependent DNA helicase activity • helicase activity • hydrolase activity • ATP binding • protein binding • DNA binding • histone deacetylase activity • RNA binding • zinc ion binding Cellular component • nucleolus • nucleoplasm • cytoplasm • nucleus • NuRD complex • centrosome • cytoskeleton • microtubule organizing center Biological process • GO:0006350 transcription, DNA-templated • chromatin assembly or disassembly • spindle organization • regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • chromatin organization • histone deacetylation • DNA duplex unwinding • regulation of signal transduction by p53 class mediator • covalent chromatin modification • centrosome cycle Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1107	216848
Ensembl	ENSG00000170004	ENSMUSG00000018474
UniProt	Q12873	n/a
RefSeq (mRNA)	NM_001005271 NM_001005273 NM_005852	NM_146019
RefSeq (protein)	NP_001005271 NP_001005273 NP_005843	n/a
Location (UCSC)	Chr 17: 7.88 – 7.91 Mb	Chr 11: 69.34 – 69.37 Mb
PubMed search

1107

216848

ENSG00000170004

ENSMUSG00000018474

Q12873

n/a

NM_001005271
NM_001005273
NM_005852

NM_146019

NP_001005271
NP_001005273
NP_005843

n/a

Chromodomain-helicase-DNA-binding protein 3 is an enzyme that in humans is encoded by the CHD3 gene.

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

CHD3 has been shown to interact with:

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Wikipedia