CHAF1B

CHAF1B
Identifiers
Aliases	CHAF1B, CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7, chromatin assembly factor 1 subunit B
External IDs	MGI: 1314881 HomoloGene: 48346 GeneCards: CHAF1B
Gene ontology Molecular function • unfolded protein binding • histone binding • chromatin binding • protein binding Cellular component • cytoplasm • cytosol • CAF-1 complex • nucleoplasm • protein complex • nuclear chromatin • nucleus Biological process • chromatin assembly • regulation of transcription, DNA-templated • protein complex assembly • transcription, DNA-templated • cellular response to DNA damage stimulus • DNA replication-dependent nucleosome assembly • DNA replication • cell cycle • DNA repair Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8208	110749
Ensembl	ENSG00000159259	ENSMUSG00000022945
UniProt	Q13112	Q9D0N7
RefSeq (mRNA)	NM_005441	NM_028083
RefSeq (protein)	NP_005432	NP_082359
Location (UCSC)	Chr 21: 36.39 – 36.42 Mb	Chr 16: 93.88 – 93.91 Mb
PubMed search

8208

110749

ENSG00000159259

ENSMUSG00000022945

Q13112

Q9D0N7

NM_005441

NM_028083

NP_005432

NP_082359

Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene.

Chromatin assembly factor I (CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.

CHAF1B has been shown to interact with:

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Wikipedia