CGMP-specific phosphodiesterase type 5

PDE5A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OEX, 1RKP, 1T9R, 1T9S, 1TBF, 1UDT, 1UDU, 1UHO, 1XOZ, 1XP0, 2CHM, 2H40, 2H42, 2H44, 2XSS, 3B2R, 3BJC, 3HC8, 3HDZ, 3JWQ, 3JWR, 3LFV, 3MF0, 3SHY, 3SHZ, 3SIE, 3TGE, 3TGG, 4G2W, 4G2Y, 4I9Z, 4IA0, 4MD6, 4OEW
Identifiers
Aliases	PDE5A, CGB-PDE, CN5A, PDE5, phosphodiesterase 5A
External IDs	OMIM: 603310 MGI: 2651499 HomoloGene: 842 GeneCards: PDE5A
Gene ontology Molecular function • nucleotide binding • 3',5'-cyclic-nucleotide phosphodiesterase activity • cGMP binding • metal ion binding • cyclic-nucleotide phosphodiesterase activity • catalytic activity • phosphoric diester hydrolase activity • hydrolase activity • 3',5'-cyclic-GMP phosphodiesterase activity Cellular component • cytosol Biological process • regulation of cGMP metabolic process • positive regulation of MAP kinase activity • cGMP metabolic process • positive regulation of cardiac muscle hypertrophy • cGMP catabolic process • negative regulation of T cell proliferation • positive regulation of oocyte development • metabolic process • relaxation of cardiac muscle • signal transduction • negative regulation of cardiac muscle contraction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8654	242202
Ensembl	ENSG00000138735	ENSMUSG00000053965
UniProt	O76074	Q8CG03
RefSeq (mRNA)	NM_033437 NM_001083 NM_033430	NM_153422
RefSeq (protein)	NP_001074 NP_236914 NP_246273	NP_700471.2 NP_700471
Location (UCSC)	Chr 4: 119.49 – 119.63 Mb	Chr 3: 122.73 – 122.86 Mb
PubMed search

4OEX, 1RKP, 1T9R, 1T9S, 1TBF, 1UDT, 1UDU, 1UHO, 1XOZ, 1XP0, 2CHM, 2H40, 2H42, 2H44, 2XSS, 3B2R, 3BJC, 3HC8, 3HDZ, 3JWQ, 3JWR, 3LFV, 3MF0, 3SHY, 3SHZ, 3SIE, 3TGE, 3TGG, 4G2W, 4G2Y, 4I9Z, 4IA0, 4MD6, 4OEW

...
Wikipedia