CETN3

CETN3
Identifiers
Aliases	CETN3, CDC31, CEN3, centrin 3
External IDs	MGI: 1097706 HomoloGene: 74521 GeneCards: CETN3
Gene location (Human) Chr. Chromosome 5 (human) Band No data available Start 90,392,261 bp End 90,409,786 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band No data available Start 81,783,292 bp End 81,797,143 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • protein binding • metal ion binding Cellular component • cytoplasm • microtubule organizing center • centriole • centrosome • nucleolus • cytoskeleton • nucleus Biological process • cell cycle • centrosome cycle • cell division Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1070	12626
Ensembl	ENSG00000153140	ENSMUSG00000021537
UniProt	O15182	O35648
RefSeq (mRNA)	NM_004365 NM_001297765 NM_001297768	NM_007684
RefSeq (protein)	NP_001284694 NP_001284697 NP_004356	NP_031710
Location (UCSC)	Chr 5: 90.39 – 90.41 Mb	Chr 5: 81.78 – 81.8 Mb
PubMed search

1070

12626

ENSG00000153140

ENSMUSG00000021537

O15182

O35648

NM_004365
NM_001297765
NM_001297768

NM_007684

NP_001284694
NP_001284697
NP_004356

NP_031710

Centrin-3 is a protein that in humans is encoded by the CETN3 gene. It belongs to the centrin family of proteins.

The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.

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Wikipedia