CENTD3

ARAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KG5, 2LNW, 5JD0, 5JCP
Identifiers
Aliases	ARAP3, CENTD3, DRAG1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
External IDs	MGI: 2147274 HomoloGene: 11199 GeneCards: ARAP3
Gene ontology Molecular function • metal ion binding • phosphatidylinositol-3,4-bisphosphate binding • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • GTPase activator activity Cellular component • cytosol • cell projection • membrane • plasma membrane • cytoskeleton • lamellipodium • ruffle • cytoplasm Biological process • positive regulation of GTPase activity • negative regulation of Rac protein signal transduction • cytoskeleton organization • regulation of small GTPase mediated signal transduction • vesicle-mediated transport • signal transduction • negative regulation of cell migration • negative regulation of Rho protein signal transduction • regulation of cell shape Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64411	106952
Ensembl	ENSG00000120318	ENSMUSG00000024451
UniProt	Q8WWN8	Q8R5G7
RefSeq (mRNA)	NM_022481	NM_001205336 NM_139206
RefSeq (protein)	NP_071926	NP_001192265.1 NP_631945.2 NP_001192265 NP_631945
Location (UCSC)	Chr 5: 141.65 – 141.68 Mb	Chr 18: 37.97 – 38 Mb
PubMed search

2KG5, 2LNW, 5JD0, 5JCP

64411

106952

ENSG00000120318

ENSMUSG00000024451

Q8WWN8

Q8R5G7

NM_022481

NM_001205336
NM_139206

NP_071926

NP_001192265.1
NP_631945.2
NP_001192265
NP_631945

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.

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Wikipedia