CENTD1

ARAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X40, 2COD
Identifiers
Aliases	ARAP2, CENTD1, PARX, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
External IDs	MGI: 2684416 HomoloGene: 9064 GeneCards: ARAP2
Gene ontology Molecular function • phosphatidylinositol-3,4,5-trisphosphate binding • metal ion binding • GTPase activator activity Cellular component • cytoplasm • cytosol Biological process • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	116984	212285
Ensembl	ENSG00000047365	ENSMUSG00000037999
UniProt	Q8WZ64	Q8BZ05
RefSeq (mRNA)	NM_015230 NM_139182	NM_178407
RefSeq (protein)	NP_056045	n/a
Location (UCSC)	Chr 4: 35.95 – 36.24 Mb	Chr 5: 62.6 – 62.77 Mb
PubMed search

1X40, 2COD

116984

212285

ENSG00000047365

ENSMUSG00000037999

Q8WZ64

Q8BZ05

NM_015230
NM_139182

NM_178407

NP_056045

n/a

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. This protein lacks the predicted catalytic arginine in the RHO-GAP domain and is therefore unlikely to have RHO-GAP activity. While the encoded protein does contain a sterile alpha motif (SAM) commonly found in some signaling molecules, the function of the protein has not been determined. Two transcript variants encoding different isoforms have been found for this gene.

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