CDX2

CDX2
Identifiers
Aliases	CDX2, CDX-3, CDX2/AS, CDX3, caudal type homeobox 2, Cdx2
External IDs	MGI: 88361 HomoloGene: 968 GeneCards: CDX2
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • double-stranded DNA binding Cellular component • transcriptional repressor complex • nucleoplasm • protein complex • condensed nuclear chromosome • nucleus Biological process • pattern specification process • cell differentiation • regulation of transcription, DNA-templated • regulation of somitogenesis • somatic stem cell population maintenance • endosome to lysosome transport • placenta development • regulation of transcription from RNA polymerase II promoter • labyrinthine layer development • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription, DNA-templated • multicellular organism development • blood vessel development • trophectodermal cell differentiation • establishment or maintenance of epithelial cell apical/basal polarity • positive regulation of cell differentiation • intestinal epithelial cell differentiation • positive regulation of cell proliferation • animal organ morphogenesis • anterior/posterior axis specification • blastocyst development • anterior/posterior pattern specification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1045	12591
Ensembl	ENSG00000165556	ENSMUSG00000029646
UniProt	Q99626	P43241
RefSeq (mRNA)	NM_001265	NM_007673
RefSeq (protein)	NP_001256	NP_031699.2 NP_031699
Location (UCSC)	Chr 13: 27.96 – 27.97 Mb	Chr 5: 147.3 – 147.31 Mb
PubMed search

1045

12591

ENSG00000165556

ENSMUSG00000029646

Q99626

P43241

NM_001265

NM_007673

NP_001256

NP_031699.2
NP_031699

Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. This gene is a member of the caudal-related homeobox transcription factor family that is expressed in the nuclei of intestinal epithelial cells.

Cdx2 is the gene that directs early embryogenesis in mice. It is required to form the placenta.

Ectopic expression of CDX2 was reported in more than 85% of the human patients with acute myeloid leukemia (AML). Ectopic expression of Cdx2 in murine bone marrow induced AML in mice and upregulate Hox genes in bone marrow progenitors. CDX2 is also implicated in the pathogenesis of Barrett's esophagus where it has been shown that components from gastroesofageal reflux such as bile acids are able to induce the expression of an intestinal differentiation program through up-regulation of NF-κB and CDX2.

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Wikipedia