CDKN2A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E

Identifiers

Aliases

CDKN2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A

External IDs

OMIM: 600160 MGI: 104738 HomoloGene: 55430 GeneCards: CDKN2A

Gene ontology
Molecular function	• NF-kappaB binding • protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • protein kinase binding • RNA binding • DNA binding • p53 binding • transcription factor binding • MDM2/MDM4 family protein binding • ubiquitin-protein transferase inhibitor activity • SUMO transferase activity
Cellular component	• cytoplasm • cytosol • senescence-associated heterochromatin focus • nucleus • nuclear body • nucleoplasm • protein complex • nucleolus • mitochondrion
Biological process	• senescence-associated heterochromatin focus assembly • positive regulation of smooth muscle cell apoptotic process • negative regulation of cyclin-dependent protein serine/threonine kinase activity • replicative senescence • G1/S transition of mitotic cell cycle • negative regulation of cell-matrix adhesion • cellular senescence • negative regulation of cell growth • cell cycle arrest • positive regulation of cellular senescence • positive regulation of macrophage apoptotic process • cell cycle • Ras protein signal transduction • negative regulation of phosphorylation • negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • negative regulation of cell proliferation • apoptotic process • regulation of G2/M transition of mitotic cell cycle • regulation of transcription, DNA-templated • regulation of protein stability • negative regulation of immature T cell proliferation in thymus • regulation of protein export from nucleus • negative regulation of protein kinase activity • negative regulation of proteolysis involved in cellular protein catabolic process • protein K63-linked ubiquitination • positive regulation of signal transduction by p53 class mediator • somatic stem cell division • protein stabilization • protein polyubiquitination • positive regulation of protein sumoylation • transcription, DNA-templated • positive regulation of transcription, DNA-templated • mitophagy • apoptotic mitochondrial changes • regulation of protein targeting to mitochondrion • protein destabilization • negative regulation of ubiquitin-protein transferase activity • positive regulation of apoptotic process • rRNA processing • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • mitochondrial depolarization • positive regulation of DNA damage response, signal transduction by p53 class mediator • negative regulation of B cell proliferation • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of apoptotic DNA fragmentation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cell cycle arrest • positive regulation of protein localization to nucleus • protein sumoylation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1029


12578

Ensembl


ENSG00000147889


ENSMUSG00000044303

UniProt


P42771 Q8N726


P51480 Q64364

RefSeq (mRNA)


NM_000077 NM_001195132 NM_058195 NM_058196 NM_058197


NM_001040654 NM_009877

RefSeq (protein)


NP_000068.1 NP_001182061.1 NP_478104.2 NP_478102.2


NP_001035744.1 NP_034007.1

Location (UCSC)

Chr 9: 21.97 – 22 Mb

Chr 4: 89.27 – 89.29 Mb

PubMed search

2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E

NM_000077
NM_001195132
NM_058195
NM_058196
NM_058197

NM_001040654
NM_009877

...
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