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CDK1

CDK1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDK1, CDC2, CDC28A, P34CDC2, cyclin-dependent kinase 1, cyclin dependent kinase 1
External IDs OMIM: 116940 MGI: 88351 HomoloGene: 68203 GeneCards: CDK1
Targeted by Drug
dinaciclib
RNA expression pattern
PBB GE CDC2 203213 at tn.png

PBB GE CDC2 203214 x at tn.png

PBB GE CDC2 210559 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007659

RefSeq (protein)

NP_001163877
NP_001163878
NP_001307847
NP_001777
NP_203698

NP_031685.2
NP_031685

Location (UCSC) Chr 10: 60.78 – 60.79 Mb Chr 10: 69.34 – 69.35 Mb
PubMed search

4YC6, 4Y72, 5HQ0, 4YC3

NM_001320918

NM_007659

NP_001163877
NP_001163878
NP_001307847
NP_001777
NP_203698

NP_031685.2
NP_031685

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. In humans, Cdk1 is encoded by the CDC2 gene. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates (over 75 have been identified in budding yeast); phosphorylation of these proteins leads to cell cycle progression.


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Wikipedia

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