CDH13

CDH13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V37
Identifiers
Aliases	CDH13, CDHH, P105, cadherin 13
External IDs	OMIM: 601364 MGI: 99551 HomoloGene: 20335 GeneCards: CDH13
Genetically Related Diseases
periodontitis, schizophrenia, mental depression, attention deficit hyperactivity disorder
Gene ontology Molecular function • calcium ion binding • protein homodimerization activity • adiponectin binding • cadherin binding • metal ion binding • low-density lipoprotein particle binding • lipoprotein particle binding Cellular component • cytoplasm • membrane • focal adhesion • plasma membrane • perinuclear region of cytoplasm • caveola • anchored component of membrane • neuron projection • extracellular exosome • external side of plasma membrane • extracellular space Biological process • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • regulation of endocytosis • positive regulation of smooth muscle cell proliferation • negative regulation of cell adhesion • positive regulation of calcium-mediated signaling • positive regulation of endothelial cell proliferation • positive regulation of cell-matrix adhesion • positive regulation of cell migration • low-density lipoprotein particle mediated signaling • regulation of epidermal growth factor receptor signaling pathway • sprouting angiogenesis • response to organic substance • positive regulation of positive chemotaxis • keratinocyte proliferation • cell adhesion • Rho protein signal transduction • mitotic cell cycle • Rac protein signal transduction • localization within membrane • adherens junction organization • endothelial cell migration • negative regulation of cell proliferation • lamellipodium assembly • homophilic cell adhesion via plasma membrane adhesion molecules • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1012	12554
Ensembl	ENSG00000140945	ENSMUSG00000031841
UniProt	P55290	Q9WTR5
RefSeq (mRNA)	NM_001220488 NM_001220489 NM_001220490 NM_001220491 NM_001220492 NM_001257	NM_019707
RefSeq (protein)	NP_001207417 NP_001207418 NP_001207419 NP_001207420 NP_001207421 NP_001248	NP_062681.2 NP_062681
Location (UCSC)	Chr 16: 82.63 – 83.8 Mb	Chr 8: 118.28 – 119.32 Mb
PubMed search

2V37

1012

12554

ENSG00000140945

ENSMUSG00000031841

P55290

Q9WTR5

NM_001257

NM_019707

NP_001248

NP_062681.2
NP_062681

T-cadherin also known as cadherin 13, H-cadherin (heart) (CDH13) is a unique member of cadherin superfamily because it lacks the transmembrane and cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. Classical cadherins are necessary for cell–cell contacts, dynamic regulation of morphogenetic processes in embryos and tissue integrity in adult organism. Cadherins function as membrane receptors mediating outside-in signals, activating small GTPases and beta-catenin/Wnt pathway, and resulting in dynamic cytoskeleton reorganization and changes in the phenotype.

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