CDC5L

CDC5L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIM, 2DIN
Identifiers
Aliases	CDC5L, CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1, cell division cycle 5 like
External IDs	MGI: 1918952 HomoloGene: 13291 GeneCards: CDC5L
Gene ontology Molecular function • DNA binding • protein phosphatase 1 binding • leucine zipper domain binding • WD40-repeat domain binding • protein binding • transcription corepressor binding • protein kinase binding • sequence-specific DNA binding • transcription factor activity, RNA polymerase II transcription factor recruiting • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • RNA binding Cellular component • cytoplasm • nuclear speck • catalytic step 2 spliceosome • membrane • Prp19 complex • nucleoplasm • protein-DNA complex • perinuclear region of cytoplasm • DNA replication factor A complex • spliceosomal complex • nucleus Biological process • mRNA splicing, via spliceosome • cellular response to nerve growth factor stimulus • regulation of transcription, DNA-templated • mRNA processing • cellular response to fibroblast growth factor stimulus • transcription, DNA-templated • cellular response to interleukin-2 • cellular response to prolactin • cellular response to DNA damage stimulus • signal transduction involved in DNA damage checkpoint • cellular response to wortmannin • mitotic cell cycle • cell cycle • DNA repair • cell differentiation • RNA splicing • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	988	71702
Ensembl	ENSG00000096401	ENSMUSG00000023932
UniProt	Q99459	Q6A068
RefSeq (mRNA)	NM_001253	NM_152810
RefSeq (protein)	NP_001244	NP_690023.1 NP_690023
Location (UCSC)	Chr 6: 44.39 – 44.45 Mb	Chr 17: 45.39 – 45.43 Mb
PubMed search

2DIM, 2DIN

988

71702

ENSG00000096401

ENSMUSG00000023932

Q99459

Q6A068

NM_001253

NM_152810

NP_001244

NP_690023.1
NP_690023

Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.

CDC5L has been shown to interact with:

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Wikipedia