CD79

CD79a molecule, immunoglobulin-associated alpha
Identifiers
Symbol	CD79A
Alt. symbols	IGA
Entrez	973
HUGO	1698
OMIM	112205
RefSeq	NM_001783
UniProt	P11912
Other data
Locus	Chr. 19 q13.2

CD79b molecule, immunoglobulin-associated beta
Identifiers
Symbol	CD79B
Alt. symbols	IGB
Entrez	974
HUGO	1699
OMIM	147245
RefSeq	NM_021602
UniProt	P40259
Other data
Locus	Chr. 17 q23

CD79 (Cluster of Differentiation 79) is a transmembrane protein that forms a complex with the B-cell receptor (BCR) and generates a signal following recognition of antigen by the BCR. CD79 is composed of two distinct chains called CD79A and CD79B (formerly known as Ig-alpha and Ig-beta); these form a heterodimer on the surface of a B cell stabilized by disulfide bonding. CD79a and CD79b are both members of the immunoglobulin superfamily. Human CD79a is encoded by the mb-1 gene that is located on chromosome 19, and CD79b is encoded by the B29 gene that located on chromosome 17. Both CD79 chains contain an immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails that they use to propagate a signal in a B cell, in a similar manner to CD3-generated signal tranduction observed during T cell receptor activation on T cells.