CD63

CD63
Identifiers
Aliases	CD63, LAMP-3, ME491, MLA1, OMA81H, TSPAN30, CD63 molecule
External IDs	OMIM: 155740 MGI: 99529 HomoloGene: 37526 GeneCards: CD63
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • multivesicular body • endosome • multivesicular body membrane • membrane • late endosome membrane • intrinsic component of plasma membrane • melanosome • plasma membrane • integral component of plasma membrane • endosome lumen • multivesicular body, internal vesicle • lysosomal membrane • extracellular region • platelet dense granule membrane • lysosome • endosome membrane • extracellular exosome • extracellular space • cell surface • azurophil granule membrane Biological process • positive regulation of receptor internalization • platelet degranulation • pigment granule maturation • cellular protein localization • transport • endosome to melanosome transport • regulation of rubidium ion transport • protein transport • positive regulation of integrin-mediated signaling pathway • cell-matrix adhesion • cell migration • neutrophil degranulation • regulation of vascular endothelial growth factor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	967	12512
Ensembl	ENSG00000135404	ENSMUSG00000025351
UniProt	P08962	P41731
RefSeq (mRNA)	NM_001780 NM_001040034 NM_001257389 NM_001257390 NM_001257391 NM_001257392 NM_001257400 NM_001257401 NM_001267698	NM_001042580 NM_001282966 NM_007653
RefSeq (protein)	NP_001244318 NP_001244319 NP_001244320 NP_001244321 NP_001244329 NP_001244330 NP_001254627 NP_001771	NP_001036045.1 NP_001269895.1 NP_031679.1 NP_001036045 NP_001269895 NP_031679
Location (UCSC)	Chr 12: 55.73 – 55.73 Mb	Chr 10: 128.91 – 128.91 Mb
PubMed search

967

12512

ENSG00000135404

ENSMUSG00000025351

P08962

P41731

NM_001257392
NM_001257400
NM_001257401
NM_001267698

NM_001042580
NM_001282966
NM_007653

NP_001244330
NP_001254627
NP_001771

NP_031679

CD63 antigen is a protein that in humans is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with HermanskyPudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins.

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Wikipedia