CD47

CD47
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JJS, 2JJT, 2VSC, 4CMM, 4KJY, 5IWL
Identifiers
Aliases	CD47, IAP, MER6, OA3, CD47 molecule
External IDs	MGI: 96617 HomoloGene: 1346 GeneCards: CD47
Gene ontology Molecular function • thrombospondin receptor activity • protein binding Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane • specific granule membrane • extracellular exosome • tertiary granule membrane Biological process • integrin-mediated signaling pathway • positive regulation of phagocytosis • cell adhesion • extracellular matrix organization • positive regulation of inflammatory response • positive regulation of T cell activation • response to bacterium • leukocyte migration • positive regulation of cell proliferation • opsonization • positive regulation of cell-cell adhesion • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	961	16423
Ensembl	ENSG00000196776	ENSMUSG00000055447
UniProt	Q08722	Q61735
RefSeq (mRNA)	NM_001025079 NM_001025080 NM_001777 NM_198793	NM_010581
RefSeq (protein)	NP_001768 NP_942088	NP_034711.1 NP_034711
Location (UCSC)	Chr 3: 108.04 – 108.09 Mb	Chr 16: 49.86 – 49.92 Mb
PubMed search

2JJS, 2JJT, 2VSC, 4CMM, 4KJY, 5IWL

961

16423

ENSG00000196776

ENSMUSG00000055447

Q08722

Q61735

NM_001025079
NM_001025080
NM_001777
NM_198793

NM_010581

NP_001768
NP_942088

NP_034711.1
NP_034711

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). This is because the protein IAP produced by CD-47 acts as a don't eat me signal to the immune system and drives organ fibrosis.

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